RSA CE&C 2015-2021 Group descriptions

86 introducing supramolecular units for folding into active components. The folded structures are reminiscent of enzymes. All this requires the sophisticated use of both organic and polymer chemistry. Analogous systems that are compatible with organic media are also developed. The assembly of such folded polymers is studied to understand how they can be triggered to transform into larger systems using a stimulus. 1B. Fundamentals of self-assembly In the field of synthetic polymer chemistry, the synthesis of well-defined covalent polymers and copolymers is well-established. Copolymers with desired microstructures and properties are attained by tuning monomer reactivities, which are embedded in their molecular structures. As a next step, we aim to translate this understanding of monomer design versus monomer reactivity to the realm of supramolecular (co)polymerizations. To achieve this, we use an integrated approach. On the one hand, we combine monomer synthesis with studies on themicrostructure of the formedpolymers and copolymers.On the other hand, we use mathematical models that permit the extraction of the thermodynamic parameters of the systems. In addition, we study how the monomer structure relates to the dynamic behavior of the polymer system and how the microstructure achieved in solution can be preserved in bulk. We do these studies in both organic media and water. Our ultimate aim is to elucidate the relationship between polymer morphology, chemical structure and assembly mechanism with the dynamic behavior of the exchange processes . 2A Green and bio-orthogonal catalysis We apply the SCPNs as carrier materials for attaching catalysts whereby homogeneous catalytic systems of nanometer-size are obtained in water. These nanoparticles act as hydrophobic reaction sites and accelerate reactions in water and complex cellular environments. We investigate a range of organocatalytic, photocatalytic and transition metal-based reactions to achieve green conversions in water. In addition, we select catalysts capable of bio-orthogonal chemistry in complex media. Our ultimate goals are to use non- natural catalytic reactions in concert with enzymes to achieve cascade catalytic reactions and to activate prodrugs in the vicinity of diseased tissue. 2B. Dynamic polymers for re-processable crosslinked materials Of particular interest is the development of crosslinked materials applied in coatings and smart materials that can be easily repaired and reused because such chemical networks are very stable and difficult to re-process. The introduction of semi-permanent chemical crosslinks into the materials will allow a balance between the desired material properties and the reuse of such crosslinked materials. We focus on supramolecular motifs that